Pharmaceutical Intermediates
OVERVIEW
Varsal has extensive technical capabilities in developing and manufacturing sophisticated Pharmaceutical Intermediates at our GMP-compliant facilities. We custom manufacture pharmaceutical materials that are not listed below upon request—please contact us for more information!
Toluenesulfonylmethyl Isocyanide (TosMIC)
- Other names: tosylmethyl isocyanide, p-Toluenesulfonylmethylisocyanide, TosMIC
- Molecular weight: 195.24
- Appearance: colorless crystalline powder, off-white to yellowish
- CAS#: 36635-61-7
Used as an intermediate for various reasons, including in the Van Leusen reaction which is used to convert aldehydes to nitriles or in the preparation of oxazoles and imidazoles.
Three of TosMIC’s mission-critical industrial applications are:
- To convert carbonyl groups to nitriles as a cyanating reagent
- To synthesize heterocyclic compounds such as oxazoles, imidazoles and pyrroles
- To prepare Knoevenagel-type condensation products
- Pharmaceutical
- Agriculture
- Food
- Electronics
Varsal is one of the world’s leading producers of TosMIC, and one of the few producers capable of producing large-scale, pharma-grade material. Varsal’s proprietary manufacturing and treatment process allows it to produce extremely high purity material with low residual impurities, low loss on drying, and low residue on ignition, leading to maximal yield and product quality for Varsal’s customers.
N,N’-dicyclohexylcarbodiimide (DCC)
- Other names: Bis(cyclohexyl)carbodiimide, 1,3-dicyclohexylcarbodiimide
- Molecular weight: 206.33
- Appearance: white to slight yellow crystalline solid
- CAS#: 538-75-0
Used as an intermediate for various reasons, including to couple amino acids during artificial peptide synthesis.
- Pharmaceutical
Varsal’s material has extremely high purity with low residual impurities and low loss on drying, leading to maximal yield and product quality for Varsal’s customers.
Acetamidine Hydrochloride
- Other names: ethanimidamide, ethanamidine acetimidamide, carboxamidine, carboximidamide
- Molecular weight: 94.54
- Appearance: white or yellowish long prismatic crystals
- CAS#: 124-42-5
Used as a Vitamin B1 building block, strong non-ionic nucleophile, intermediate in antihypertensive APIs, guanidine derivative.
- Pharmaceutical
- Personal Care
- Industrial
Varsal leverages its deep chlorination and technical manufacturing resources to produce material that has extremely high purity with low residual impurities, low moisture and low loss on drying, leading to maximal yield and product quality for Varsal’s customers.
3-oxo-2-phenylbutanamide
- Other names: 2-phenyl-acetoacetic acid amide, 2-phenyl-acetessigsaeure-amid, 2-phenyl-3-oxobutanamide
- Molecular weight: 177.20
- Appearance: white powder
- CAS#: 4433-77-6
Used as a pharmaceutical intermediate.
- Pharmaceutical
Varsal leverages its deep technical manufacturing resources to produce material that has extremely high purity with low residual impurities, low moisture and low loss on drying, leading to maximal yield and product quality for Varsal’s customers.
Mechlorethamine Hydrochloride
- Other names: Chlormethine hydrochloride, Mechlorethamine HCl
- Molecular weight: 192.52
- Appearance: white crystalline powder
- CAS#: 55-86-7
API in anti-tumor drugs (DNA alkylation of guanines), psoriasis, vitiligo, mycosis fungoides, can also be used as an immunosuppressant.
- Pharmaceutical
Varsal leverages its deep chlorination and technical manufacturing resources to produce material that has extremely high purity with low residual impurities, low moisture, low residue on ignition and low loss on drying, leading to maximal yield and product quality for Varsal’s customers.
Trifluorotoluene
- Other names: Benzotrifluoride (BTF), α,α,α-Trifluorotoluene
- Molecular weight: 146.11
- Appearance: clear, colorless liquid
- CAS#: 98-08-8
Used as a specialty solvent in organic synthesis and an intermediate in the production of pesticides and pharmaceuticals.
- Pharmaceutical
- Agriculture
Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.
2,6-Dibromopyridine
- Other names: N/A
- Molecular weight: 236.89
- Appearance: light brown to white crystals
- CAS#: 626-05-1
Used as an intermediate for a variety of applications, including as a tridentate chelating ligand and in macrocycle formation contained in the terpyridine moiety. It is also used to produce 6-bromo-2-methoxypyridine.
- Pharmaceutical
- Specialty Industrial
Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.
5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone
- Other names: 8-(Benzyloxy)-5-[(2R)-oxiran-2-yl]quinolin-2(1H)-one, 5-(2R)-2-Oxiranyl-8-(phenylmethoxy)-2(1H)-quinolinone, Indacaterol Intermediate
- Molecular weight: 293.32
- Appearance: white to light yellow crystalline powder
- CAS#: 173140-90-4
Used in a variety of applications, including as an indacaterol intermediate used in the preparation of hydroxyquinoline substituted aminoindans as β2-adrenoceptor agonists with potentials as ultralong-acting bronchodilators.
- Pharmaceutical
Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.
Benzyl Indacaterol
- Other names: (R)-8-(Benzyloxy)-5-[2-(5,6-diethylindan-2-ylamino)-1-hydroxyethyl]-1H-quinolin-2-one, Indacaterol Intermediate
- Molecular weight: 482.61
- Appearance: white to light yellow crystalline powder
- CAS#: 435273-75-9
Used in a variety of applications, including as a reactant in the preparation of Indacaterol (I499745)—a β-adrenoreceptor agonist.
- Pharmaceutical
Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.
benzyl ((S)-2-((tert-butoxycarbonyl)amino)-4-phenylbutanoyl)-L-leucyl-L-phenylalaninate
- Other names: Carfilzomib Intermediate
- Molecular weight: 629.79
- Appearance: white or off-white powder
- CAS#: 868540-15-2
Used as a reactant in the preparation of the anti-cancer medication API and selective proteasome inhibitor Carfilzomib.
- Pharmaceutical
Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.
Cyclobutylmethylamine hydrochloride
- Other names: Cyclobutylmethanamine HCl
- Molecular weight: 121.61
- Appearance: off-white to pale brown solid
- CAS#: 5454-82-0
Used in a variety of applications, including as a reactant in the preparation of cyclobutylarachidonylamide.
- Pharmaceutical
Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.
2-HYDROXY-6-METHOXYBENZALDEHYDE
- Other names: 6-Methoxysalicylaldehyde
- Molecular weight: 152.15
- Appearance: pale yellow to pale brown powder
- CAS#: 700-44-7
Used in a variety of applications, including as a pharmaceutical intermediate.
- Pharmaceutical
Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.
2,6-Dimethoxybenzaldehyde
- Other names: N/A
- Molecular weight: 166.17
- Appearance: white to green crystalline powder
- CAS#: 3392-97-0
Used in a variety of applications, including in the preparation of 2,6-dihydroxybenzaldehyde by demethylation with AlBr3.
- Pharmaceutical
Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.
4-[1-(4,5-DIHYDRO-4,4-DIMETHYL-2-OXAZOLYL)-1-METHYLETHYL]-BENZENEETHANOL
- Other names: 2-[4-[1-(4,4-dimethyl-5H-oxazol-2-yl)-1-methyl-ethyl]phenyl]ethanol, Bilastine Intermediate
- Molecular weight: 261.36
- Appearance: white to off-white powder
- CAS#: 361382-26-5
Used in the production of Bilastine—a second-generation antihistamine API for treating allergic rhinoconjunctivitis and urticaria.
- Pharmaceutical
Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.
O-(2-(vinyloxy)ethyl)hydroxylamine
- Other names: 1-[2-(aminooxy)ethoxy]ethylene
- Molecular weight: 103.12
- Appearance: colorless to yellow liquid
- CAS#: 391212-29-6
Used in a variety of applications, including in the synthesis of various heterocyclic compounds as mitogen-activated protein kinase MEK inhibitors (i.e. Binimetinib).
- Pharmaceutical
Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.
(R)-3-Amino-1-butanol
- Other names: (3R)-3-Amino-1-butanol
- Molecular weight: 89.14
- Appearance: colorless to yellow liquid
- CAS#: 61477-40-5
Used in a variety of applications, including as a key intermediate of the HIV/AIDS treatment medication Dolutegravir. Its green and efficient biosynthesis makes it an attractive candidate for a large range of applications.
- Pharmaceutical
Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.
6-Chloro-1-hexene
- Other names: N/A
- Molecular weight: 118.6
- Appearance: colorless to yellow liquid
- CAS#: 928-89-2
6-Chloro-1-hexene is an ω-chloro-1-alkene, and is mainly used as a pharmaceutical intermediate, including in the synthesis of 1-(5-hexen)-2,3-dimethyl-imidazolium chloride. It reacts with β-substituted imines in the presence of a rhodium catalyst to afford tri- and tetra-substituted imines, and undergoes cross-coupling reaction in the presence of copper(II) chloride and 1-phenylpropyne.
- Pharmaceutical
Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.
7-Chloro-1-heptene
- Other names: 7-Chlorohept-1-ene
- Molecular weight: 132.63
- Appearance: colorless to pale yellow liquid
- CAS#: 929-21-5
7-Chloro-1-heptene is used as a pharmaceutical intermediate in a variety of applications.
- Pharmaceutical
Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.
L-Arginine ethyl ester dihydrochloride (L-AEE)
- Other names: N/A
- Molecular weight: 275.18
- Appearance: white to pale yellow powder
- CAS#: 36589-29-4
L-AEE has a variety of applications, and is commonly used to study the structure and function of proteins and other molecules within biochemical, physiological, and drug development studies.
- Pharmaceutical
Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.
4-[[(Fluorophenyl)-imino]-methyl]-phenol (FMP)
- Other names: N/A
- Molecular weight: 215.23
- Appearance: Off-white to yellow to tan powder
- CAS#: 3382-63-6
FMP is an intermediate of Ezetimibe, and is used in the preparation of benzylacetones which promote anti-fungal activity. FMP has a variety of uses as a Schiff base, and has demonstrated nonlinear optical properties.
- Pharmaceutical
- Environmental
- Industrial
Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.
Dihydro-2H-pyran-3(4H)-one
- Other names: N/A
- Molecular weight: 100.12
- Appearance: Colorless to yellow liquid or solid
- CAS#: 23462-75-1
Used as a chemical reagent in the synthesis of pharmaceuticals such as the preparation of tetrahydropyran-2-yl chromans, a highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE) inhibitor.
- Pharmaceutical
Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.
(S)-1-Methyl-5-oxopyrrolidine-2-carboxylic acid
- Other names: N/A
- Molecular weight: 143.14
- Appearance: Off-white to yellow solid
- CAS#: 52574-06-8
Used as a chemical intermediate in the synthesis of various pharmaceuticals.
- Pharmaceutical
Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.