Specialty Intermediates

Overview

Varsal supplies a range of technical intermediates that deliver mission-critical performance for specialized and niche applications. Leveraging deep technical expertise, Varsal supports the development and supply of tailored solutions to help customers address their most complex challenges.

Product Index

Select a product to view technical details.

(CAS# 23112-96-1)

(CAS# 16419-60-6)

(CAS# 843663-18-3)

(CAS# 31886-58-5)

(CAS# 31886-57-4)

(CAS# 62871-09-4)

(CAS# 7766-50-9)

(CAS# 30674-80-7)

trans-Cyclobutane-1,2-dicarboxylic acid

Used as a specialty intermediate for various reasons, including as a diacid monomer or cross-linker for producing thermoplastics and thermosets.

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.

2-[2-(Methacryloyloxy)ethyloxy]ethyl isocyanate

Used as a specialty material for a variety of reasons due to its attractive qualities as a dual-functional monomer.

Varsal’s Product M is used to produce urethane methacrylates, as it shows higher reactivity towards polyols compared to traditional aliphatic isocyanates. Thus, the formed urethane methacrylates exhibit high reactivity and sensitivity.

It can also be used to produce acrylic isocyanate copolymers. The formed products are stable to free radicals, so they are able to react in the presence of peroxides or azo compounds.

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.

2-Isocyanatoethyl methacrylate (IEM)

Used as a specialty intermediate for a variety of reasons, including as a cross-linker for resins and coatings.

Varsal is a leading producer of extremely-high-purity IEM. We are differentiated from the competition as Varsal’s proprietary manufacturing logistics processes allows us to produce consistent, stable, extremely-high-purity material—leading to maximal yield and product quality for Varsal’s customers.

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers. Extremely high purity in monomers such as IEM is important because of the sheer diversity of obtainable products from different polymerization systems, with a variety of reaction kinetics. Even trace impurities can significantly affect product quality and lead to poor reproducibility of desired compounds.

3-(TRIFLUOROMETHYL)-1H-PYRAZOLE

Used as a specialty intermediate (building block) for various reasons, such as synthesis of ligands for OLEDs.

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.

3,5-Dichloro-2,4,6-trifluoropyridine

Used as a specialty intermediate for a variety of reasons, including in the preparation of affinity gels used in the purification of immunoglobulin G.

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.

Bis[4-(hexyloxy)phenyl]methanone

Used as a specialty material for various reasons, including as a photoinitiator in crosslinking extruded polyolefins.

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.

Cyclobutanemethanol

Used in a variety of applications, including in the synthesis of bicyclic lactones. Lactones are in many natural products used in the flavors and fragrances industry, and also exhibit attractive antioxidant, antimicrobial, and anticancer properties.

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.

2,6-Dimethoxyphenylboronic acid

Used in a variety of applications, including as a reagent in the Pd-catalyzed Suzuki-Miyaura coupling reaction to construct a carbon-carbon bond; in the synthesis of 2H-imidazo[1,5-a]pyridin-4-ium bromides, which are precursors in the preparation of N-heterocyclic carbene ligands; and, in the preparation of monosubstituted benzothiazoloquinazolinones as potential monoamine oxidases inhibitors.

Additionally, it is a common reactant in Suzuki-Miyaura reactions, which have widespread usage in the synthesis of pharmaceutical intermediates, fine chemicals, and other complex compounds.

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.

2-Amino-5-methoxypyridine

Used in a variety of applications, including C. difficile toxin inhibitor synthesis.

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.

2-Tolylboronic acid

Used as a reagent in a variety of applications, including:

Palladium-catalyzed direct arylation of pyrazoles with phenylboronic acids
Pd-catalyzed arylation using Suzuki-Miyaura cross-coupling in water
Ruthenium catalyzed direct arylation reactions
Ligand-free copper-catalyzed coupling reactions
Copper-catalyzed cross-coupling reactions of diaryl diselenides
Phosphine-free Suzuki-Miyaura cross-coupling reactions
Rhodium-catalyzed asymmetric 1,4-addition reactions
Chiral monophosphorus ligands in asymmetric Suzuki-Miyaura coupling reaction
Palladium nanoparticles immobilized by click ionic copolymers as recyclable catalysts for Suzuki-Miyaura cross-coupling reaction in water
Human farnesyl pyrophosphate synthase inhibitors as antitumor agents for multiple myeloma cells

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.

4-CYANO-3-FLUOROPHENYLBORONIC ACID

Used in a variety of applications, including in the Suzuki-Miyaura reactions, which have widespread usage in the synthesis of pharmaceutical intermediates, fine chemicals, and other complex compounds.

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.

2-(5-Methoxypyridin-2-yl)acetic acid

Used as an intermediate in a variety of applications.

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.

Formamidine acetate

Used in a variety of applications, including in the synthesis of active pharmaceutical ingredients and as a condensing agent for the preparation of pyrimidine and imidazole heterocycles.

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.

4-Hydroxy-2-butanone

Used as an intermediate in a variety of applications, including the synthesis of:

Fused benzazepine molecules as selective D3 receptor antagonists
Verrucarin and mevalonic acid lactone
3-buten-2-one through dehydration over an anatase titanium dioxide catalyst
4-methyl-5-hydroxymethylthiazole, lineatin, beta-hydroxylactones

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.

(R)-N,N-Dimethyl-1-ferrocenylethylamine

Used as a starting material in a variety of processes, including synthesis of chiral 1,2-disubstituted ferrocenyl amino alcohols, ferrocene-based P-chiral phosphine ligands, and optically active α-ferrocenyl tertiary amines. It is also a ligand used in the preparation of chiral allylic alcohols, axially chiral allenecarboxylic esters, and the rhodium(I)-catalyzed asymmetric hydrosilylation of ketones.

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.

(S)-N,N-Dimethyl-1-ferrocenylethylamine

Used as a starting material in the synthesis of chiral diferrocenylphosphine-diamines applicable to catalysis, and as a model chiral probe in the study of enantiodiscrimination ability of chiral ionic liquids using cyclic voltammetry.

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.

7-Bromo-1-heptene

7-Bromo-1-heptene is a linear halogenated alkene commonly used as an alkylating agent. This material may be used to synthesize a range of compounds, including:

9-hept-6-enyloxy-5-hydroxymethyl-2-isopropyl-1-methyl-1,4,5,6-tetrahydro-2H-benzo[e][1,4] diazocin-3-one
boc-L-2-amino-8-nonenoic acid
8-hydroxy-15,15,15-trifluoro-1-pentadece

It is also used as a reagent in the synthesis of (R)-(+)-Lasiodiplodin, a macrolide that exhibits potent antileukemic activity against human tumors.

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.

8-Bromo-1-octene

8-Bromo-1-octene has been used in preparation of polymerizable ligands, required for the synthesis of quantum dot-labeled polymer beads. A Grignard reagent derived from 8-bromo-1-octene has been used in the synthesis of (2S,3S,5R)-5-[(1R)-1-hydroxy-9-decenyl]-2-pentyltetrahydro-3-furanol.

It has been used as a building block in natural product synthesis, as well as in the synthesis of more complex pharmaceutical compounds, such as Dithienogermole derivatives with varying alkyl chain lengths and pendant functionalities.

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.

9-Bromo-1-nonene

9-Bromo-1-nonene is used as a key intermediate in organic synthesis, agrochemical, pharmaceutical and dyestuff applications.

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.

10-Bromo-1-decene

10-Bromo-1-decene is a key starting material for production of 1-decene, an alpha olefin used in a variety of applications. Such uses include serving as a comonomer, and as an intermediate in production of epoxides, amines, oxo alcohols, synthetic lubricants, synthetic fatty acids and alkylated aromatics.

10-Bromo-1-decene may also be used to synthesize:

4′-(9-decenyloxy)biphenyl-4-carboxylic acid methyl ester
4′-(9-decenyloxy)biphenyl-4-carboxylic acid
9-decenylmagnesium bromide

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.

11-Bromo-1-Undecene

11-Bromo-1-undecene is a halogenated hydrocarbon with a wide variety of uses in advanced polymer dielectrics.

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.

3-Bromopentane

3-Bromopentane is a glass forming liquid used in various chemical synthesis applications, including in the preparation of 2-(1-ethyl-propoxy)-isoindole-1,3-dione, and in the process of cobalt-catalyzed ortho alkylation of aromatic imines

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.

8-chloro-1-octene

8-chloro-1-octene comonomer is useful as an additive in the production of polymers of Ziegler hydrocarbons (e.g., polyethylene, polypropylene, poly-4-methyl-1-pentene). Incorporating a small amount of this compound increases the polymer’s suitability for dyeing and vulcanization.

8-chloro-1-octene has also been used in the preparation of modified polymers with aromatic groups, and may be used for alkene halogenation in the manufacture of heat-resistant polylactic acid extrusion foams. Another use of this chloroalkene is in the production of silane compounds that contain a mercapto group.

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.

Cyclopentyl methyl ether (CPME)

CPME is used in a variety of applications, including Grignard Reaction, Suzuki Coupling, Buchwald Amination, Metal Reductions (NaBH4, LiAlH4, i-Bu2AlH), Reactions with n-BuLi, Reactions with Lewis Acid, Friedel Crafts Reactions. It is also used in extractions, crystallizations, polymerizations and coatings.

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.

Specialty Intermediates

Overview

Product Index

trans-Cyclobutane-1,2-dicarboxylic acid

2-[2-(Methacryloyloxy)ethyloxy]ethyl isocyanate

2-Isocyanatoethyl methacrylate (IEM)

3-(TRIFLUOROMETHYL)-1H-PYRAZOLE

3,5-Dichloro-2,4,6-trifluoropyridine

Bis[4-(hexyloxy)phenyl]methanone

Cyclobutanemethanol

2,6-Dimethoxyphenylboronic acid

2-Amino-5-methoxypyridine

2-Tolylboronic acid

4-CYANO-3-FLUOROPHENYLBORONIC ACID

2-(5-Methoxypyridin-2-yl)acetic acid

Formamidine acetate

4-Hydroxy-2-butanone

(R)-N,N-Dimethyl-1-ferrocenylethylamine

(S)-N,N-Dimethyl-1-ferrocenylethylamine

7-Bromo-1-heptene

8-Bromo-1-octene

9-Bromo-1-nonene

10-Bromo-1-decene

11-Bromo-1-Undecene

3-Bromopentane

8-chloro-1-octene

Cyclopentyl methyl ether (CPME)

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